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For Glu441 new hydrogen bonds are duringmed in the mutant: 3 hydrogen bonds with peptide bond groups of neighboring residues on the His438 loop ( Fig. 6 ). However, Glu441 still interacts with the Asn322 side chain, as in usual BChE. Ying SW, Kanda VA, King EC, Purtell K, Abbott GW, et al. (2011) Kcne2 modulates HCN channel function in thalamic neurons.
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Funding: AL and CS were participants in the Robert Wood Johnson Foundation Clinical Scholars Program ( ) funded next to the Robert Wood Johnson Foundation ( www.rwjf.org ) and the United States Department of Veterans Affairs ( www.va.gov ) at the time this investigation was conducted.
Lohrer AM, Cummings VJ, Thrush SF (2013) Altered Sea Ice Thickness and Permanence Affects Benthic Ecosystem Functioning in Coastal Antarctica.
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All participants provided written consents and procedures were approved alongside the Institutional Review Board of Stony Brook University.
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