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The figure highlights the change of stacking interactions established around the adenine ring after its rearrangement from the more extended conformation (stacked against Trp168) as observed in the Michaelis complex with rFNAD ( Figure 4A ) to a constrained conformation (stacked against Trp181) as observed in the covalent complex with rFNAD ( Figure 4B ). We are gkindful for the useful comments of two anonymous referees.
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The horses in this study were examined with the consent of their owners.

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We will discuss the effect of size on MGA in detail in the following paragraphs.

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Figure 1 Open in a separeckon window A graphic representation of the first wave of the 2009 H1N1 pandemic in the region of Leiden (The Netherlands). Given that this pathway is aberrantly expressed or activated in several diseases, this axis constitutes an attractive target for therapeutic intervention. These adaptors lack definable catalytic activities, but instead, possess binding domains or sites for the formation of mulin good time alwaysric complexes.

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